1. Vitamin D – especially beneficial in patients with musculoskeletal pain; A trial which added 4,000 iu/day of vitamin D reduced daily pain and need for analgesic rescue medication vs. placebo. In addition, several inflammatories decreased by 39.2% to 54.3% in the group treated with vitamin D (Gendelman, Itzhaki, & Amital, 2014).
2. Magnesium – known deficiency in American population; A trial evaluating the role of magnesium replacement in patients with chronic low back pain found those receiving magnesium over 6 weeks vs placebo noted reduced pain intensity and improvement in lumbar spine mobility during a 6-month follow up period (Yousef & Al-deeb, 2013).
3. Omega 3s – U.S. adults do not have adequate intake of anti-inflammatory fatty acids including EPA and DHA; Several studies have noted that marine-derived n-3 polyunsaturated fatty acids supplementation provided significant reduction of inflammatory markers. (Li et al., 2014).
4. B Vitamins – deficiencies in several of the B vitamins have been linked to pain; Studies show carnitine demonstrated benefit in treating fibromyalgia pain when compared to prescription medication (Leombruni et al., 2015).
Source: The Andrew Weil Center for Integrative Medicine
Gendelman, O., Itzhaki, D., & Amital, H. (2014). AB0873 A Randomized Double-Blind Placebo-Controlled Study Adding High Dose Vitamin D to Analgesic Regimens in Patients with Musculoskeletal Pain: Table 1. Annals of the Rheumatic Diseases, 73(Suppl 2). doi:10.1136/annrheumdis-2014-eular.2555
Yousef, A. A., & Al-deeb, A. E. (2013, March). A double-blinded randomised controlled study of the value of sequential intravenous and oral magnesium therapy in patients with chronic low back pain with a neuropathic component. Anaesthesia, 68(3), 260-266. doi: 10.1111/anae.12107
Li, K., Huang, T., Zheng, J., Wu, K., & Li, D. (2014). Effect of Marine-Derived n-3 Polyunsaturated Fatty Acids on C-Reactive Protein, Interleukin 6 and Tumor Necrosis Factor α: A Meta-Analysis. PLoS ONE, 9(2). doi:10.1371/journal.pone.0088103.
Leombruni, P., Miniotti, M., Colonna, F., Sica, C., Castelli, L., Bruzzone, M., Parisi, S., Fusaro, E., Sarzi-Puttini, P., Atzeni, F., & Torta, R. G. (2015). .A randomised controlled trial comparing duloxetine and acetyl L-carnitine in fibromyalgic patients: preliminary data. Clinical and Experimental Rheumatology, 33(1 Suppl 88), S82-S85. Epub 2015 Mar 18.